Bioinspired Photonic Microchip with Molecularly Imprinted Polymer for Single Recognition of c-Myc Protein in Predictive Medical Diagnostics

Monitoring of trace c-Myc protein as the biomarker of ubiquitous cancers is critical in achieving predictive medical diagnostics. However, qualitative and quantitative detection of c-Myc protein with superior single selectivity and sensitivity is still challenging. Herein, a bioinspired photonic sensing microchip for single recognition of c-Myc protein is outlined with two synergistic aspects involving chemical and physical design criteria. Chemical design uses specific molecularly imprinted polymer (MIP) with exquisite complementarity in its chemical functions and spatial geometries to targeted c-Myc protein, leading to excellent sensitivity and selectivity for single identification. Physical design involves optical geometrical double-reflection polarization rotation and multilayer interference of the fabricated periodic photonic architecture inspired by Papilio palinurus butterfly wings to enhance the spectral diversity of reflectance. Therefore, a one-of-a-kind sensing platform integrates the advantages of MIP and bioinspired photonic structure is demonstrated to actualize distinctive signal conversion and amplification for qualitative and quantitative detection of trace c-Myc protein, accompanied with superior sensitivity (detection limit is 0.014 mu g mL(-1)), selectivity, stability, anti-interference ability as well as rapid response/recovery time. This sensor microchip uniquely ventures into the territory of functionally combining bioinspired photonic structure with MIP absorbers, proven promising for prevention or diagnosis of cancers in medical field.