Traces of pubertal brain development and health revealed through domain adapted brain network fusion

Puberty demarks a period of profound brain dynamics that orchestrates changes to a multitude of neuroimaging-derived phenotypes. This poses a dimensionality problem when attempting to chart an individual’s brain development on a single scale. Here, we illustrate shifts in subject similarity of imaging data that relate to pubertal maturation and altered mental health, suggesting that dimensional reference spaces of subject similarity render useful to chart brain dynamics in youths. ### Competing Interest Statement The authors have declared no competing interest. ### Funding Statement Authors DK and TK were funded by the Faculty of Medicine, University of Tuebingen. TK was also funded by the Research Council of Norway (# 323961). D.A. was funded by the South Eastern Norway Regional Health Authority (#2019107, #2020086). TK is a member of the Machine Learning Cluster of Excellence, EXC number 2064/1 Project number 39072764. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study uses only human data that has been shared under the data use agreements of the respective cohorts (i.e., ABCD, PNC, HBN) I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes Data incorporated in this work were gathered from various resources (see acknowledgements) and are shared under data use agreements of the respective cohorts. Data incorporated in this work were gathered from various resources (see acknowledgements) and are shared under data use agreements of the respective cohorts.