Cohort profile: The Westlake BioBank for Chinese (WBBC) pilot cohort: a prospective study for the late adolescence

medrxiv(2020)

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摘要
Purpose The Westlake BioBank for Chinese (WBBC) pilot cohort is a population-based prospective study with its major purpose to better understand the effect of genetic and environmental factors on growth and development from adolescents to adults. The dataset comprises a wide range of demographics, anthropometric measures, physical activity, sleep quality, age at menarche and bone mineral density. Participants A total of 14,726 participants (4,751 males and 9975 females) aged 14 to 25 years were recruited and the baseline survey was carried out from 2017 to 2019. The pilot cohort contains rich range of information regarding of demographics, anthropometric measurements, blood pressure and heart rate, lifestyle and sleep patterns, biological, clinical and health outcomes. Findings to date There were most of the participants were Chinese Han ethnic (97.78%), and more than 60% of them were originally from rural areas. For anthropometry measurements, the mean height and weight were 172.92 cm and 65.81 kg for men, and 160.13 cm and 52.85 kg for women; the mean waist, hip and thigh circumference were 75.51cm, 90.75cm and 51.56 cm in men, and 71.67cm, 89.75cm and 51.68 among women. Results indicated that the prevalence of underweight in female was much higher than male, but the prevalence of overweight and obesity in female was lower than male. The mean of serum 25(OH)D level in the 14,726 young participants was 22.39 ng/ml, and male had higher level of serum 25(OH)D than female, overall, 33.47% of the participants had vitamin D deficiency and even more participants suffered from vitamin D insufficiency (58.17%). The proportion of deficiency in women was much higher than that in men (41.83 vs. 16.35%). Future plans WBBC is designed as a prospective cohort study and provides a unique and rich data set analyzing health trajectories of Chinese adolescents to young adults. ### Competing Interest Statement Jun-Quan Liu and Yi Sun are employees of Hangzhou Kingmed Diagnostics Co., Ltd. The other authors have no conflict of interest to declare. ### Clinical Trial ChiCTR1900024703 ### Funding Statement This study was supported by the National Natural Science Foundation of China (81871831), and by the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China (LR17H070001), and by the Westlake Biobank for Chinese (WBBC) funds from Westlake University. ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: the Ethics Committees at Westlake University All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes The data is not freely available in the public domain, but specific proposals and ideas for future collaboration would be very welcome.
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