Correlation between early antibiotic therapy and in-hospital mortality in patients with community acquired infection

Sepsis is defined as the systemic response to an infectious disease, whether caused by bacteria, viruses, fungi or protozoa. Sepsis has several etiologies according to the worsening of the disease, those of bacterial origin with 70%, of which Gram-negative bacilli are the most frequent, especially in patients with the most severe disease. The most common community infections are respiratory infections, urinary tract infections and skin infections, with elderly individuals and children being more susceptible to complications of the immune system. The objective of this research is to analyze whether the time between hospitalization and the start of antibiotic treatment is directly related to the mortality rate and length of stay. This study was carried out in the form of documentary field research, where data collection was performed using data from the medical records of patients diagnosed with community infection or sepsis. Data collection was carried out from a form where patient identification, age, infectious focus, date and time of admission to the emergency room, date and time of the 1st dose of antibiotic, time interval between admission and antibiotic administration, ICU stay, days of mechanical ventilation and outcome. 34 patients were followed up in the emergency room and in the ICU, with an average age of these patients is 71.4 ± 30 years. This research showed a high mortality rate of the included patients who were diagnosed with community infection. ### Competing Interest Statement The authors have declared no competing interest. ### Clinical Trial CAAE 3.641.058 Brazil ### Funding Statement Self funding ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Accordind brazilian resoltion 466/2012 and 510/2016 about ethics in research. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived. Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable. Yes www.datasus.gov.br