Responses in fast-spiking interneuron firing rates to parameter variations associated with degradation of perineuronal nets

The perineuronal nets (PNNs) are sugar coated protein structures that encapsulate certain neurons in the brain, such as parvalbumin positive (PV) inhibitory neurons. As PNNs are theorized to act as a barrier to ion transport, they may effectively increase the membrane charge-separation distance, thereby affecting the membrane capacitance. Tewari et al. ( 2018 ) found that degradation of PNNs induced a 25