Detection of Keratoconus with a new Corvis Biomechanical Index Optimized for Chinese Population (cCBI).

Two thousand four hundred and seventy-three patients (healthy and keratoconus) were included. In the database 2, the Area Under the Curve (AUC) of the cCBI was 0.985 with a 93.4 % specificity and 95.5 % sensitivity. In the same Dataset the original CBI produced an AUC of 0.978 with a 68.1 % specificity and 97.7 % sensitivity. There was a statistically significant difference between the ROC curve of cCBI and CBI (De Long p=0.0009) CONCLUSION: :The new cCBI for Chinese patients was shown to be statistically significantly better when compared to CBI to separate healthy from keratoconic eyes. The presence of an external validation dataset confirms this finding and suggests the use of cCBI in everyday clinical practice to aid in the diagnosis of keratoconus in Chinese ethnicity.