Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism.

Molecular metabolism（2023）

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摘要

Ces2a and CES2 are critical players in hepatic lipid signaling likely via the hydrolysis of DAG and lysoPC at the ER.

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关键词

Carboxylesterase 2,DAG accumulation,Insulin resistance,Lipid signaling,Lysophosphatidylcholine,NAFLD,Obesity

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