Early neurofilament light and glial fibrillary acidic protein levels improve predictive models of multiple sclerosis outcomes.

Gauruv Bose,Brian C Healy,Shrishti Saxena,Fermisk Saleh,Anu Paul,Christian Barro,Hrishikesh A Lokhande,Mariann Polgar-Turcsanyi,Mark Anderson,Bonnie I Glanz,Charles R G Guttmann,Rohit Bakshi,Howard L Weiner,Tanuja Chitnis

Multiple sclerosis and related disorders（2023）

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摘要

Early biomarker levels modestly improve predictive models containing clinical and MRI variables. Worse clinical outcomes, SPMS and EDSS, are associated with higher sGFAP levels and worse MRI outcomes, T2LV and BPF, are associated with higher sNfL levels. Prospective study implementing these predictive models into clinical practice are needed to determine if early biomarker levels meaningfully impact clinical practice.

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关键词

Biomarkers,Glial fibrillary acidic protein,Multiple sclerosis,Neurofilament,Outcomes,Predictive models

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