Evaluation of Early Single Dose Vaccination on Swine Influenza A Virus Transmission in Piglets: from Experimental Data to Mechanistic Modelling.

•We evaluated swine influenza A transmission virus in piglets with different MDA statuses after a single-dose vaccination.•The transmission rate of the challenge strain was found 3.6 time greater in MDA-positive than in MDA-negative pigs.•Estimated parameters were unsed to feed a mechanistic model of SwIAV transmission in a farrow-to-finish pig farm.•An extended SwIAV within-farm persistence was observed when both sows and piglets were batch-to-batch vaccinated.•Alternative vaccination schemes need to be tested, accounting for population dynamics and hosts’ immune statuses.