一株红树林真菌Phoma herbarum L28的代谢产物

研究了内生真菌草茎点霉Phoma herbarum L28的次级代谢产物.该菌纯化自红树林植物苦槛蓝Myoporum bontioides A.Gray,通过大米发酵培养.采用色谱层析、波谱分析等技术分离鉴定了10个单体化合物fusarihexin A(1),fusarihexin B(2),botryosphaerihydrofuran(3),N1-methyl-2-pyridone-5-carboxamide(4),4′,5,6-trihydroxy-7-methoxyisoflavone(5),ascomfuran A(6),4-羟基苯乙酸(7),protocatechuic acid(8),胸腺嘧啶脱氧核苷(9),nortetillapyrone(10).其中化合物1,2,3,4,5,10为首次从Phoma属中分离获得.二倍稀释法抗菌测试显示化合物1,2对O78血清型大肠杆菌Escherichia coli(禽致病性),化合物3和10对小麦赤霉菌Fusarium graminearum,化合物4对番茄枯萎菌Fusarium oxysporum显示强抗菌活性.