Increased NOX2 expression in astrocytes leads to eNOS uncoupling through dihydrofolate reductase in endothelial cells after subarachnoid hemorrhage.

Shu-Hao Miao,Sheng-Qing Gao,Hui-Xin Li, Yun-Song Zhuang,Xue Wang,Tao Li,Chao-Chao Gao,Yan-Ling Han,Jia-Yin Qiu,Meng-Liang Zhou

Frontiers in molecular neuroscience（2023）

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摘要

The increased level of NOX2 in astrocytes contributes to decreased DHFR in endothelial cells, thus aggravating eNOS uncoupling, which is an essential mechanism underlying acute vasoconstriction after SAH.

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关键词

acute cerebral ischemia,acute vasoconstriction,dihydrofolate reductase,endothelial nitric oxide synthase uncoupling,neurovascular unit,nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2),subarachnoid hemorrhage

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