Eculizumab Rescue Therapy in Patients With Recurrent Atypical Hemolytic Uremic Syndrome After Kidney Transplantation.

Caroline Duineveld,Romy N Bouwmeester,Kioa L Wijnsma, F J Bemelman, J W van der Heijden,S P Berger,L P W J van den Heuvel,Nicole C A J van de Kar,Jack F M Wetzels

Kidney international reports（2023）

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摘要

Rescue treatment of posttransplant aHUS recurrence is effective; however, some patients suffer from irreversible loss of kidney function, likely caused by delayed diagnosis and treatment and/or too aggressive discontinuation of eculizumab. Physicians should be aware that recurrence of aHUS can present without evidence of systemic TMA.

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atypical hemolytic uremic syndrome,eculizumab,kidney transplantation,thrombotic microangiopathy

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