Study on Antibody Fc-glycosylation for Optimal Effector Functions.

Vidya S. S. Shivatare,Po-Kai Chuang,Tzu-Hao Tseng,Yi-Fang Zeng,Han-Wen Huang,Gannedi Veeranjaneyulu,Han-Chung Wu,Chi-Huey Wong

CHEMICAL COMMUNICATIONS（2023）

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摘要

A comprehensive structure-activity relationship study on antibody Fc-glycosylation has been performed using the chimeric anti-SSEA4 antibody chMC813-70 as a model. The α-2,6 sialylated biantennary complex type glycan was identified as the optimal Fc-glycan with significant enhancement in antibody effector functions, including binding to different Fc receptors and ADCC.

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关键词

Fc? Receptors,Fc Receptors,Glycosylation

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