Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma.
Cancer discovery(2023)
摘要
Using single-cell-resolved multiplexed imaging, we show that selected subpopulations of cells expressing specific combinations of oncogenes influence clinical outcomes in lymphoma. We describe a probabilistic metric for the estimation of cellular oncogenic coexpression from IHC or bulk transcriptomes, with possible implications for prognostication and therapeutic target discovery in cancer.
更多查看译文
关键词
oncogene coexpression,lymphoma,single-cell
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要