Cryptobacterium curtum: a novel bacteria with a possible significant involvement in periodontal disease. a review.

Periodontal disease is considered to be connected with some very well-known anaerobic etiological agents. Many studies are analysing the associations between Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia with periodontal disease. Still, the prevalence of this disease is increased. In this review we aimed to present a possible new bacteria connected with periodontal disease: Cryptobacterium curtum. We performed a search in PubMed and we identified 8 articles, published between 1999 and 2018. Here we present a summary about this bacterial species regarding its microscopic, cultivation and genomic features. New molecular biology techniques, such as NGS (next generation sequencing) or mRNA technology, identified this bacteria to be associated with acute dental abscesses, and with chronic periodontitis. The virulence factors of this bacteria are not yet identified, but with the recent highly sensitive techniques, there is hope to completely establish the role of C. curtum in the pathogenesis of periodontal disease.