Gene dysregulation in acute HIV-1 infection - early transcriptomic analysis reveals the crucial biological functions affected.

Erica Parker,Melinda A Judge,Lucia Pastor,Laura Fuente-Soro,Chenjerai Jairoce,Kim W Carter,Denise Anderson,Inácio Mandomando,Holly D Clifford,Denise Naniche,Peter Neils Le Souëf

Frontiers in cellular and infection microbiology（2023）

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摘要

Our study contributes to a better understanding of the mechanisms of early HIV-induced immune damage. These findings have the potential to lead to new earlier interventions that improve outcomes.

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关键词

HIV,Mozambique,acute HIV infection,gene expression profiling,host microbial interactions,innate immunity,sub-Sahara Africa (SSA)

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