Feed efficiency in dairy sheep: An insight from the milk transcriptome.
Frontiers in veterinary science(2023)
摘要
The DEA between sheep with divergent feed efficiency allowed the identification of genes associated with the immune system and stress in L-FE animals. In addition, the sPLS-DA approach revealed the importance of genes involved in cell division (e.g., and ) and cellular lipid metabolic process (e.g., , and ) for the H-FE sheep in the lactating mammary gland transcriptome. A set of discriminant genes, commonly identified by the two statistical approaches, was also detected, including some involved in cell proliferation (e.g., , or ) or encoding heat-shock proteins (). These results provide novel insights into the biological basis of feed efficiency in dairy sheep, highlighting the informative potential of the mammary gland transcriptome as a target tissue and revealing the usefulness of combining univariate and multivariate analysis approaches to elucidate the molecular mechanisms controlling complex traits.
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关键词
RNA-Seq,dairy sheep,feed efficiency,mammary gland,sPLS-DA
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