Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles.

Lea M Stitzlein,Achintyan Gangadharan, Leslie M Walsh,Deokhwa Nam,Alexsandra B Espejo,Melissa M Singh, Kareena H Patel,Yue Lu,Xiaoping Su,Ravesanker Ezhilarasan,Joy Gumin,Sanjay Singh,Erik Sulman,Frederick F Lang,Joya Chandra

Frontiers in neurology（2023）

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摘要

Collectively, the growth inhibitory effects of LSD1 inhibition across a panel of GSC models and identification of genes that may predict resistance has potential to guide future combination therapies.

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关键词

drug resistance,epigenetics,glioblastoma,histone demethylase inhibitors,lysine specific demethylase (KDM)

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