Circulating tumor DNA analysis of the phase III VOYAGER trial: KIT mutational landscape and outcomes in patients with advanced gastrointestinal stromal tumor treated with avapritinib or regorafenib

C. Serrano,S. Bauer,D. Gómez-Peregrina,Y.-K. Kang,R.L. Jones,P. Rutkowski,O. Mir,M.C. Heinrich,W.D. Tap,K. Newberry,A. Grassian, H. Shi,S. Bialick,P. Schöffski,M.A. Pantaleo,M. von Mehren,J.C. Trent,S. George

Annals of Oncology（2023）

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摘要

CtDNA sequencing efficiently detects KIT/PDGFRA mutations and prognosticates outcomes in patients with TKI-resistant GIST treated with avapritinib. ctDNA analysis can be used to monitor disease progression and provide more personalized treatment.

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关键词

Avapritinib,GIST,KIT,PDGFRA,ctDNA,regorafenib

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