Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse.

Shuzo Sato,Xian K Zhang,Naoki Matsuoka,Yuya Sumichika,Kenji Saito,Shuhei Yoshida,Haruki Matsumoto,Jumpei Temmoku,Yuya Fujita,Tomoyuki Asano,Kiyoshi Migita

Lupus science & medicine（2023）

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摘要

Fli-1 regulates renal Sox4 mRNA expression and infiltration of CXCR5-positive cells as well as CXCL13/CD11b double-positive immune cells into the kidney, which affects CXCL13 expression and lupus-like nephritis.

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关键词

Chemokines,Inflammation,Lupus Nephritis

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