A metabolic clue for STING suppression.

Yifan Zhang,Ming-Zhu Lei,Miao Yin,Qun-Ying Lei

Trends in cell biology（2023）

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摘要

A recent report by Heath et al. reveals that obesity could impair cancer immunogenicity and foster a type I interferon (IFN-I)-deprived tumor microenvironment through saturated fatty acid-mediated stimulator of interferon genes (STING) inhibition.

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