The Anticancer Peptide LL-III Binds with Nanomolar Affinity to Human Telomeric and Cmyc G-quadruplexes.
CHEMICAL COMMUNICATIONS(2023)
摘要
LL-III is a natural anticancer peptide able to cross the membrane of cancer cells and to localize in the nucleolus, but its intracellular target is unknown. Here, we show that LL-III is able to bind with nM affinity to specific G-quadruplex structures known to be relevant anticancer targets.
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关键词
G-Quadruplexes
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