Association between diabetes risk reduction diet score and risk of breast cancer: A case-control study

Purpose: To assess the association between the diabetes risk reduction diet score (DRRD) and the odds of breast cancer (BC).Methods: During this hospital-based case-control study we included 149 newly diagnosed cases of BC and 150 controls matched by age. All cases were patients with pathologically confirmed BC, with no history of any form of other cancers. The controls were randomly selected from visitors and families of non-cancer patients in other wards of the same hospital who had no health issues including BC. The dietary intakes were evaluated by a validated 147-item semi-quantitative FFQ. DRRD score was calculated from 9 dietary components published before, with a better score resembling a higher adherence to DRRD.Results: A negative association was found between the chances of BC and DRRD after adjusting for potential confounders, but it was not statistically significant (OR, 0.47; 95%CI, 0.11-2.08; P = 0.531). Also, there were no significant associations between DRRD and therefore the odds of BC in the crude model and also in post-menopausal (OR, 0.45; 95%CI, 0.10-1.99; P = 0.505) and pre-menopausal women (OR, 0.52; 95%CI, 0.18-1.40; P = 0.097) in our study, after adjusting for potential confounders.Conclusion: Adherence to a diet with a high DRRD score was not associated with the reduced risk of BC in Iranian adults.(c) 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.