Electrochemical oxidative C(sp(3))-H/O-H cross-coupling for the synthesis of alpha-acyloxyketones

C(sp(3))-H/O-H cross-coupling represents an ideal strategy for constructing C(sp(3))-O bonds but remains challenging due to the relatively inert C(sp(3))-H bonds. Herein, we report a facile and novel electrochemical oxidative C(sp(3))-H/O-H cross-coupling method, leading to various useful a-acyloxyketones with moderate to excellent yields under transition metal- and oxidant-free conditions. A series of carboxylic acids including aromatic and aliphatic acids and ketones are compatible with this reaction.