New Paradigms in Catalysis Inspired by Cytochromes P450

Cytochromes P450 (P450s or CYPs) are versatile biocata-lysts capable of realizing a broad range of synthetically challenging re-actions. The development of synthetic catalysts/catalytic systems that model enzyme functions is a goal that has long been pursued. In this account, we mainly summarize our latest advances in the field of cataly-sis inspired by cytochromes P450, including reductive activation strate-gies for highly efficient oxidations and an unusual L-cystine-derived li-gand as a model of P450s for highly efficient iron-catalyzed undirected arene C-H hydroxylation. These new paradigms highlight some of the catalytic properties of P450s, such as effective late-stage functionaliza-tion of complex targets, good reactive functional group tolerance, and high catalytic efficiency and selectivity.1 Introduction2 Reductive Activation Strategies for Oxygenation3 An Fe/Cysteine-Based Ligand as a Biomimetic Model of Cyto-chromes P450 for Arene C-H Hydroxylation4 Conclusion