Efficiency of phosphorylated mandua starch in matrix tablet for targeted release of mesalamine in colon

The safety of the biological tissues, along with optimum drug delivery in the vicinity of targeted sites, is the utmost paramount concern of the drug delivery devices composed of synthetic and/or natural excipients. In this research work, the matrix tablets composing of phosphorylated mandua starch were developed by wet granulation method and coated with Eudragit S 100 in 5, 10 and 20% w/w of coating strength. The formulations were studied for weight variation, hardness, friability, diameter, drug content uniformity, dissolution in simulated changing over media and gastrointestinal transition by gamma scintigraphy. The cumulative drug release (% w/ w) from Eudragit S 100 coated tablets containing 5, 10 and 20% w/w coatings was 30.93, 17.62 and 16.25% w/ w, respectively within 8 h of dissolution in changing over dissolution media composing of simulated intestinal fluid (SIF, pH 6.8). In healthy rabbits, the maximum amount of radio-labelling tracer (Tc99m) was leached out in the colon, indicating successful delivery of the drug to colon. In vivo gamma scintigraphic images also revealed the transit time of 90-120 min for the gastric phase and 280-420 min for the intestinal phase. The present study reflected that phosphorylated mandua starch may act as novel drug-carrier for colon-targeted delivery of mesalamine.