Tailoring 3′ UTRs alters metastatic potential
Nature Cell Biology（2023）
摘要
In cancer, alternative polyadenylation has been shown to lead to altered 3′ UTRs with different regulatory potentials. A study now suggests a mechanism that leads to 3′ UTR lengthening and translational repression of a subset of metastasis-suppressing genes, revealing a new prospective therapeutic vulnerability.
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关键词
Breast cancer,Metastasis,RNA metabolism,Translation,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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