Alzheimer's disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs.

Karol Andrea Arizaca Maquera,Justin Ralph Welden,Giorgi Margvelani,Sandra C Miranda Sardón, Samantha Hart, Noémie Robil,Alvaro Gonzalo Hernandez, Pierre de la Grange,Peter T Nelson,Stefan Stamm

Frontiers in molecular neuroscience（2023）

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摘要

Thus, we identified novel regulated retained introns that correlate with NFT Braak stages and provide evidence for a role of translated circRNAs in AD development.

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关键词

Alzheimer,Braak stage,circular RNAs,alternative splicing,gene expression,retained intron

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