Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Supplemental Figure S1. No effect of ROCK inhibitors on the expression of ROCK1 or ROCK2. Supplemental Figure S2. ROCK1 and ROCK2 knockdown, dose-response relationships and IC50 determinations for AT13148 on cell morphology parameters. Supplemental Figure S3. Dose-response relationships for AT13148 on nuclear morphology parameters. Supplemental Figure S4. No effect of ROCK inhibitor treatment on mouse weights. Supplemental Figure S5. AT13148 blocks PDAC tumor growth in vivo.