Supplementary Data from Chromosomal Instability and mTORC1 Activation through PTEN Loss Contribute to Proteotoxic Stress in Ovarian Carcinoma

Supplementary Figure S1. Chromosome missegregation in FTSECs by pharmacologic inhibition of Mps1 and CENP-E (relates to Figures 1 and 2); Supplementary Figure S2. Comparisons of monolayer versus spheroid cultures of ovarian cancer cells (relates to Figure 4); Supplementary Figure S3. Marker expression in ovarian cancer cell cultures (relates to Figure 4); Supplementary Figure S4. mTORC1 activation potentiates aneuploidy-associated UPR induction, while suppression of mTORC1 by rapamycin causes mild cytostatic effects (relates to Figure 5); Supplementary Figure S5. mTORC1 activation sensitizes to bortezomib in ovarian cancer cells (relates to Figure 5); Supplementary Figure S6. PTEN loss sensitizes to bortezomib in TOV1946 xenografts (relates to Figure 6); Supplementary Table S1. List of primary antibodies; and Supplementary Methods.