Figure S1 to S10 from Clonality, Heterogeneity, and Evolution of Synchronous Bilateral Ovarian Cancer

Supplementary Figure S1. Representative images of hematoxylin and eosin (H&E) staining and computed tomography from each patients.Supplementary Figure S2. Distribution of cancer-predisposition genes in each patient. Blue: splice site; dark gray: single nucleotide variations; light gray: absent. Supplementary Figure S3. SciClone analysis of sequenced tumor samples from RJOC12. Supplementary Figure S4. Circos plot displays the copy number variations and inter- and intra-chromosal translocations. Supplementary Figure S5. Heat maps display the Cancer Cell Fraction (CCF) of all mutations in both ovarian lesions of RJOC1-11 (up). Phylogenetic tree of both ovarian tumors were constructed from all somatic mutations. Supplementary Figure S6. Mutation signatures of SNVs in early and late stages. Supplementary Figure S7. Mutational signatures of SBOCs. Supplementary Figure S8. SciClone analysis of 11 SBOC patients. Supplementary Figure S9. Pyclone analysis of 11 SBOC patients.Supplementary Figure S10. Germline and somatic alterations of DNA repair genes.