Supplementary figure 2 from Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF–CRAF Heterodimerization

Lise Boussemart,Isabelle Girault,Hélène Malka-Mahieu,Christine Mateus,Emilie Routier, Margot Rubington,Nyam Kamsu-Kom, Marina Thomas, Gorana Tomasic,Sandrine Agoussi, Marie Breckler,Mélanie Laporte,Ludovic Lacroix, Alexander M. Eggermont,Andrea Cavalcanti,Florent Grange,Julien Adam,Stéphan Vagner,Caroline Robert

crossref（2023）

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摘要

Vemurafenib-induced BRAF-CRAF dimerization (2 µM, 24h) detected by in situ PLA in SK-MEL2 cell line is not decreased by the adjunction of MEK inhibitor PD0325901 (1µM, 24h): each red dot represents a BRAF-CRAF heterodimer. The cells were counterstained with DAPI (blue).

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