Supplemental Figures 1-6 from Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis

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摘要

Supplemental figures (1-6) demonstrate the efficacy of parental SIX1/EYA2 inhibitor, synthesis of compound 8430, endogenous SIX1 and EYA2 expression in tumor lines, as well as 8430's transcriptional impact, pharmacokinetic/toxicity and effect on metastasis.

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