Supplemental Figures 1 through 8 from mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

Figure S1: Loss of Rictor does not prevent pancreatic formation or function. Figure S2: Rictor deletion decreases proliferation in PanIN1 lesions. Figure S3: Rictor deletion alters CDKI and BMI1 expression and localization. Figure S4: Rictor deletion does not affect response to caerulein-induced pancreatic injury. Figure S5: Absence of mTORC2 activity increases the nuclear expression of CDKIs in PanIN1 lesions driven by KrasG12D and caerulein-induced pancreas injury. Figure S6: Rictor knockdown impairs the transformed phenotype in murine PDAC cells. Figure S7: AZD2014 treatment blocks signaling downstream of mTORC1 and mTORC2. Figure S8: AZD2014 and AZD8186 co-treatment blocks downstream mTORC2 targets.