Supplementary Figures S1-S7 from <i>ATMIN</i> Is a Tumor Suppressor Gene in Lung Adenocarcinoma

Supplementary figure S1. ATM is altered in LUAD and reduced expression correlates with poor survival. Supplementary figure S2. ATMIN and ATM immunohistochemical staining on LUAD and adjacent normal lung tissue. Supplementary figure S3. LUAD tumors deficient for Atmin or Atm exhibit activation of MAPK pathway and increase cell proliferation. Supplementary figure S4. Deletion of Atmin or Atm increases LUAD tumor burden. Supplementary figure S5. AtminÎ"L/+ KP tumor cells-maintained expression of Atmin target gene Dynll1. Supplementary figure S6. Homozygous and Heterozygous Atmin loss increases cell proliferation and tumor grafts. Supplementary figure S7. ATM and ATMIN deficiency confers resistance to replication stress.