Swept-source Optical Coherence Tomography Detects Anterior-Chamber Changes in Patients with Angle-Closure after Laser Peripheral Iridotomy

Purpose: This study aimed to compare an teriorchamber parameters acquired by a swept -source anteriorsegment optical coherence tomography before and after laser peripheral iridotomy. Methods: This study prospectively evaluated 14 patients with primary -angle closure and six patients with primary -angle closure glaucoma. Gonioscopy and anterior -segment optical coherence tomography using the DRI OCT Triton (R) were performed before and after laser peripheral iridotomy. Anterior -segment optical coherence tomography parameters were studied using scleral spur as reference: angle opening distance at 250, 500, and 750 gm, trabecular-iris space at 500 gm, trabecular-iris angle, trabecular-iris contact length, and iris curvature. Result: Anterior -segment optical coherence tomography identified 61% of the patients with two or more quadrants closed. Gonioscopy identified more closed angles than anterior -segment optical coherence tomography before laser peripheral iridotomy. In angle parameters, only the angle opening distance of 250 gm at the nasal quadrant was not significantly increased after laser peripheral iridotomy. The iris curvature and trabecular-iris contact length showed a significant reduction induced by the laser procedure. Even in eyes in which gonioscopy did not identify angular widening after laser peripheral iridotomy (n=7), the angle opening distance of 750 gm increased (nasal, 0.15 +/- 0.10 mm to 0.27 +/- 0.16 mm, p=0.01; temporal, 0.14 +/- 0.11 mm to 0.25 +/- 0.12 mm, p=0.001) and the iris curvature decreased (nasal, 0.25 +/- 0.04 mm vs. 0.11 +/- 0.07 mm, p=0.02; temporal, 0.25 +/- 0.07 mm vs. 0.14 +/- 0.08 mm, p=0.007). Conclusion: Anterior -chamber changes induced by laser peripheral iridotomy could be quantitatively evaluated and documented by DRI OCT Triton.