Supplemental Figures from CXCL12γ Promotes Metastatic Castration-Resistant Prostate Cancer by Inducing Cancer Stem Cell and Neuroendocrine Phenotypes

Supplemental Figure 1: Small cell carcinoma in PCa patient tissues. Supplemental Figure 2: Metastatic potential of CXCL12 γ expression in PCa cells and CXCL12 γ expression in normal human and mouse tissues. Supplemental Figure 3: CXCL12 γ induces CSCs, which promotes BCa tumor growth. Supplemental Figure 4: CXCL12 γ induces a NE phenotype in BCa cells. Supplemental Figure 5: Regression analyses of ENO2 mRNA expression and serum Enolase 2/NSE, Chromogranin A, and PSA in m-CRPC patients. Supplemental Figure 6: CSCs in NE PCa cells and The role of CXCL12 γ in AR-dependent PCa cells. Supplemental Figure 7: CXCL12 γ contributes activation of CXCR4-mediated PKC α /NF κ B signaling in CSC and NE inductions in BCa cells.