Pd26-06 the association between insomnia, insomnia medications, and erectile dysfunction

You have accessJournal of UrologyCME1 Apr 2023PD26-06 THE ASSOCIATION BETWEEN INSOMNIA, INSOMNIA MEDICATIONS, AND ERECTILE DYSFUNCTION Federico Belladelli, Shufeng Li, Chiyuan A. Zhang, Francesco Del Giudice, Frank Glover, Wade Muncey, Nicolas Serranio, Satvir Basran, Francesco Montorsi, Andrea Salonia, and Michael Eisenberg Federico BelladelliFederico Belladelli More articles by this author , Shufeng LiShufeng Li More articles by this author , Chiyuan A. ZhangChiyuan A. Zhang More articles by this author , Francesco Del GiudiceFrancesco Del Giudice More articles by this author , Frank GloverFrank Glover More articles by this author , Wade MunceyWade Muncey More articles by this author , Nicolas SerranioNicolas Serranio More articles by this author , Satvir BasranSatvir Basran More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , and Michael EisenbergMichael Eisenberg More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003304.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Due to its importance for health, quality and duration of sleep has been investigated. Insomnia, characterized by difficulty in falling asleep, staying asleep, or poor-quality sleep. Itaffects up to one third of adults and may impact male sexual function. In addition, the treatments for insomnia, which operate through manipulations of the central nervous system, may also affect sexual function. The current study investigated the risk of ED in patients diagnosed with and treated for insomnia. METHODS: We utilized the IBM® MarketScan® (2007 to 2016) Commercial and Medicare Supplemental Databases (v 2.0, DOI: 10.57761/ray7-1g16) Age- and enrollment date- matched controls were selected among patients without insomnia diagnosis. Cox proportional hazard models were applied to calculate the risk of incident ED (i.e. diagnosis alone, or diagnosis and treament with PDE5i , intracavernous injection (ICI)/urethral suppositories, and penile prosthesis) after the diagnosis or treatment of insomnia while adjusting for relevant comorbidities. RESULTS: In total, 182,534 men with an insomnia diagnosis were identified with a median age of 49. An additional 356,575 men diagnosed and treated for insomnia were identified with a median age of 51. The median (SD) follow-up time for patients diagnosed and diagnosed & treated for insomnia were 2.8 and 2.5 years. Men with insomnia were more commonly smokers and had a higher number of office visits and comorbidities, compared to controls (p<0.001). On adjusted analysis, both untreated and treated insomnia were associated with ED diagnosis [OR (95% CI): 1.58 (1.54-1.62) and 1.66 (1.64-1.69), respectively; p<0.001]. Similarly, men with treated insomnia had a higher odds of having ED treated with PDE5i [OR (95% CI): 1.52 (1.49-1.55); p<0.001] and ICI [OR (95% CI): 1.32 (1.14-1.54); p<0.001] when compared to controls. In contrast, men with untreated insomnia did not have higher odds of having ED treated with PDE5i [OR (95% CI): 0.97 (0.95-1.001); p<0.001] or ICI [OR (95% CI): 0.84 (0.67-1.07); p=0.02]. CONCLUSIONS: In the current report, a consistent association between insomnia and ED diagnosis was identified. Men with untreated insomnia were not prescribed PD5i or ICI for their ED. However, men with pharmacologic insomnia treatments for insomnia were more often prescribed treatments for ED suggesting that insomnia treatment may exacerbate erectile dysfunction in men. However, more severe insomnia requiring treatment leads to more severe ED is also possible. Given the prevalenec of insomnia, future studies are warranted to delineate the association between insomnia and its treatment with erectile function. Source of Funding: Data for this project were accessed using the Stanford Center for Population Health Sciences Data Core. The PHS Data Core is supported by a National Institutes of Health National Center for Advancing Translational Science Clinical and Translational Science Award (UL1TR003142) and from Internal Stanford funding. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e737 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Federico Belladelli More articles by this author Shufeng Li More articles by this author Chiyuan A. Zhang More articles by this author Francesco Del Giudice More articles by this author Frank Glover More articles by this author Wade Muncey More articles by this author Nicolas Serranio More articles by this author Satvir Basran More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Michael Eisenberg More articles by this author Expand All Advertisement PDF downloadLoading ...