PD19-06 IMPACT OF ACUTE KIDNEY INJURY ON FUTURE CARDIOVASCULAR DISEASE EVENTS AND RENAL IMPAIRMENT IN PATIENTS WITH UROLOGICAL SEPSIS

You have accessJournal of UrologyCME1 Apr 2023PD19-06 IMPACT OF ACUTE KIDNEY INJURY ON FUTURE CARDIOVASCULAR DISEASE EVENTS AND RENAL IMPAIRMENT IN PATIENTS WITH UROLOGICAL SEPSIS Naoki Fujita, Masaki Momota, Osamu Soma, Daisuke Noro, Jotaro Mikami, Shingo Hatakeyama, Hiroyuki Ito, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, and Chikara Ohyama Naoki FujitaNaoki Fujita More articles by this author , Masaki MomotaMasaki Momota More articles by this author , Osamu SomaOsamu Soma More articles by this author , Daisuke NoroDaisuke Noro More articles by this author , Jotaro MikamiJotaro Mikami More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Hiroyuki ItoHiroyuki Ito More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Kazuaki YoshikawaKazuaki Yoshikawa More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003285.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Although acute kidney injury (AKI) is a well-known risk factor of future cardiovascular disease (CVD) events and chronic kidney disease (CKD), no study has investigated the impact of AKI on CVD events and renal outcomes in patients with urological sepsis. METHODS: This prospective study included 188 patients with urological sepsis between September 2016 and September 2018. AKI was defined according to KDIGO criteria. Patients were divided into two groups: patients who developed any stage of AKI during hospitalization (AKI group) and patients who did not (non-AKI group). The primary endpoint was 1-year eGFR decline rate. In addition, we compared CVD event-free survival between two groups. Multivariable multiple regression analysis was performed to identify the risk factor of higher 1-year eGFR decline rate. RESULTS: Median age and follow-up periods were 79 years and 12 months, respectively. The number of patients in the non-AKI and AKI groups were 69 and 119, respectively. Three-month and 1-year eGFR decline rate (Figure 1A) and rate of >30% eGFR decline rate at 1-year (Figure 1B) in the AKI group were significantly higher than those in the non-AKI group. The rate of new-onset CKD at 1-year in the AKI group was significantly higher than that in the non-AKI group (Figure 1C). CVD event-free survival in the AKI group was significantly lower than that in the non-AKI group (Figure 1D; p=0.034). In multivariable analysis, AKI was selected as significant independent risk factor for higher 1-year eGFR decline rate in patients with urological sepsis (Table 2). CONCLUSIONS: AKI was a risk factor of future CVD events and renal impairment in patients with urological sepsis. We should closely follow-up patients with urological sepsis who developed AKI. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e579 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Naoki Fujita More articles by this author Masaki Momota More articles by this author Osamu Soma More articles by this author Daisuke Noro More articles by this author Jotaro Mikami More articles by this author Shingo Hatakeyama More articles by this author Hiroyuki Ito More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Kazuaki Yoshikawa More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...