Brain dysfunction in gait disorders of Caribbean Atypical Parkinsonism and Progressive Supranuclear Palsy patients: a comparative study

Abstract Here, we characterised gait and balance disorders in 16 Caribbean AP patients (mean age = 64.3 ± 6.8 years, 9F/7M), which we compared to 15 PSP-RS patients (mean age = 66.2 ± 5.9 years, 6F/9M), and 17 controls (mean age = 64.6 ± 5.1 years, 12F/5M) (Table S1), using clinical scales and gait initiation recordings. We also recorded oculomotor parameters. We measured brain atrophy using MRI imagery to calculate the Magnetic Resonance Parkinsonism Index (MRPI 2.0)(5), and performed Voxel Based Morphometry (VBM) analysis of T1 images to examine the changes in the grey and white matter volumes (GMV and WMV). To analyse the link between brain atrophy and gait and balance disorders, we performed principal and multiple factor analysis, and multi-table Partial Least square correlations.