Coupling of Heteroarene and Arenol via Nickel-Catalyzed C-H/C-OH Activation

Increasing sustainability awareness throughout society has sought to bring more atom-economy and environmentally benign synthetic methods based on simultaneous reaction transformation through ubiquitous C-H and C-O activation. This work reports a Ni-catalyzed heteroarene C-H/arenol C-OH coupling reaction, which omits the use of strong Lewis-acid additive and low atom-economy protecting reagent. The array of arenols and heteroarenes is effective in this protocol using in-situ activating reagent of pivalic anhydride. Detailed mechanistic studies and identification of intermediate have been carried out to understand the nature of catalytic reactions.