Moving Spatially Resolved Multiplexed Protein Profiling toward Clinical
CANCER DISCOVERY(2023)
摘要
The shift in cancer therapy from broadly cytotoxic agents toward "personalized" treatments that target specifi c alterations in each patient's tumor requires diagnostic pathology approaches that are quantitative and biospecimen-friendly. Novel multiplexed antibody-based imaging technologies can measure single-cell expression of over 60 proteins in intact tumor sections and hold promise for clinical oncology.
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