-Enaminones from cyclohexane-1,3-diones: Versatile precursors for nitrogen and oxygen-containing heterocycles synthesis

SYNTHETIC COMMUNICATIONS(2023)

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摘要
beta-Enaminones derived from cyclohexane-1,3-diones reveal a vast variety of bioactivities including anticonvulsant, anti-inflammatory, analgesic, etc. Further, these beta-Enaminones are versatile precursors for the synthesis of several other important heterocycles that illustrates antimicrobial, antibacterial, antifungal, antitumor, calcium channel antagonist, cardiovascular, antiviral activities, etc. Recently, reactions of various beta-enaminones with their counterpart for example aldehydes, Meldrum's acid, N-arylitaconimides, malononitriles, cyanoacetamide, arylglyoxals, ortho-hydroxybenzyl alcohols, o-hydroxystyrenes, and acenaphthoquinone have been recognized for the synthesis of different nitrogen and oxygen heterocycles involving 2-quinolone, 1,4-dihydropyridine, acridine-1,8-dione, indoles, xanthenes, chromenones, etc. These significances of beta-enaminones enthused us to assemble all newly developed methods for the creation of important nitrogen and oxygen-containing heterocycles, which are the chief attraction of this review article.
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Acridine-1,cyclohexane-1,dihydropyridine,3-dione,8-dione,β-enaminones,xanthenes
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