Editorial: Highlights in Pain Mechanisms 2021/22.

Chronic pain is one of the most widespread health problems worldwide and its management remains 13 suboptimal. Improving chronic pain management requires i) a better understanding of the 14 pathophysiological mechanisms underlying pain and ii) the development of patient-specific treatments, 15 based on the pathophysiological mechanisms involved. This article reviews 8 recently published papers 16 that have made recent advances in identifying potential therapeutic targets and/or in applying new 17 treatments based on these targets. 18The first topic of interest is parvalbumin-positive neurons, which could be associated with increased 20 sensitivity to nociceptive stimuli (Miyahara et al., 2021