Triflylpyridinium as Coupling Reagent for Rapid Amide and Ester Synthesis
Organic Letters(2023)
摘要
An effective method has been developed to facilitate the synthesis of amides and esters at ambient temperature within 5 min, in which a stable and easily accessible triflylpyridinium reagent is used. Remarkably, this method not only has a wide range of substrate compatibility but also could realize the scalable synthesis of peptide and ester via a continuous flow process. Moreover, excellent chirality retentions are presented during activation of carboxylic acid.
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关键词
triflylpyridinium,ester synthesis,coupling reagent,rapid amide
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