Fluorescently labelled vedolizumab identified macroscopic and microscopic mucosal drug distribution and target cells in patients with inflammatory bowel disease

Ruben Gabriëls,Anne van der Waaij,Matthijs Linssen,Pia Volkmer,Michael Dobosz,Dominic Robinson,Marcela Hermoso,Arend Karrenbeld,Eleonora Festen,Gerard Dijkstra,Gursah Kats-Ugurlu,Wouter Nagengast

Gastrointestinal Endoscopy（2023）

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摘要

Aims To enhance personalized medicine and predict response to biological therapeutics in inflammatory bowel diseaes (IBD) such as vedolizumab, the working mechanism should be elucidated. We aimed to visualize macroscopic and microscopic vedolizumab distribution and detect drug target cells during quantified fluorescence molecular endoscopy (QFME).

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关键词

inflammatory bowel disease,microscopic mucosal drug distribution,vedolizumab

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