Proteomic analysis identifies argininosuccinate synthetase 1 and special AT‐rich sequence binding protein 1 as reliable markers for the immunohistochemical distinction between WHO types A and B3 thymomas

Felix Bremmer,Hanibal Bohnenberger, Peter Findeisen,Stefan Welter,Alexander von Hammerstein‐Equord,Marc Hinterthaner,Denise Müller,Stefan Küffer,Satoru Okada,Alexander Marx,Philipp Ströbel

Histopathology（2023）

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摘要

Mutually exclusive epithelial expression of ASS1 in 100% of type B3 thymomas and ectopic nuclear expression of SATB1 in 92% of type A thymomas support the distinction between type A and type B3 thymomas with 94% sensitivity, 98% specificity and 96% accuracy.

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关键词

immunohistochemical distinction,proteomic analysis,synthetase,binding protein

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