Quantitative Measurement Of Multiple Mri-Based Structural Measures Of Knee Osteoarthritis - Analysis Of The Oa Biomarkers Consortium Fnih Study Cohort

Purpose: MRI is currently the most sensitive imaging modality for the evaluation of the majority of knee osteoarthritis (KOA) structural markers. KOA MR imaging biomarkers include cartilage, bone marrow lesions (BMLs), osteophytes, effusion/synovitis (ES) and Hoffa’s synovitis (HS) among others. MRI can be assessed using semi-quantitative (SQ) scoring systems by expert readers but these methods can be subjective and costly. Software-based fully quantitative measurement methods are used to make direct measurement of the size of MRI-based structures and offer an alternative to SQ scoring. We have developed the MRI Osteoarthritis Software Scoring (MOSS), a semi-automated software method to assess MRI for KOA. Understanding which combination of structural measures is most associated with KOA progression is important both to appreciate the natural progression of the disease and to potentially enrich clinical trials. The goal of our study was to analyze multiple quantitative MRI-based structural measures using a case-control model to understand the best subset of measures to predict KOA radiographic and pain progression