Fluctuation In Bone Marrow Lesions And Inflammatory Mri Markers And Concurrent Associations With Quantitative Cartilage Loss: Data From The Imi-Approach Cohort

Purpose: The IMI-APPROACH consortium is a longitudinal cohort study to combine conventional and new disease markers and to identify different OA phenotypes. It employed a multistep approach for the selection of participants, to include people with an increased likelihood of structural and/or pain progression. Study parameters used to assess structural progression include quantitative MRI of cartilage including thickness and semi-quantitative MRI scoring of cartilaginous and non-cartilaginous features of OA.