Retrospective cohort study on the effect of intraoperative methadone on postoperative pain and opioid consumption in oral and maxillofacial surgeries

Background: Opioids are commonly used for pain control after oral and maxillofacial (OMF) surgeries, despite its potential adverse physical and social effects. There has been growing evidence that intraoperative methadone helps reduce postoperative pain and opioid consumption in various surgeries. However, it has not yet been studied in OMF surgeries.